3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid

3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid - Names and Identifiers

Name	3-chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid
Synonyms	3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylicaci 3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid 3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXYLIC ACID 3-chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid 2-pyridinecarboxylic acid, 3-chloro-5-(trifluoromethyl)- (6S,7R)-Benzhydryl 7-((S)-6-(benzhydryloxy)-6-oxo-5-(((2,2,2-trichloroethoxy)carbonyl)amino)hexanamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate [6R-[6alpha,7alpha,7(R)]]-7-[[6-(Diphenylmethoxy)-1,6-dioxo-5-[[(2,2,2-trichloroethoxy)carbonyl]amino]hexyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[6-(diphenylmethoxy)-1,6-dioxo-5-[[(2,2,2-trichloroethoxy)carbonyl]amino]hexyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, diphenylmethyl ester, [6R-[6α,7α,7(R)]]- (9CI)
CAS	80194-18-9
InChI	InChI=1/C7H3ClF3NO2/c8-4-1-3(7(9,10)11)2-12-5(4)6(13)14/h1-2H,(H,13,14)

3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid - Physico-chemical Properties

Molecular Formula	C46H44Cl3N7O9S2
Molar Mass	1009.37
Density	1.45±0.1 g/cm3(Predicted)
Melting Point	125 - 127°C
Boling Point	269.6°C at 760 mmHg
Flash Point	116.9°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	0.00353mmHg at 25°C
Appearance	Solid
Color	White to Off-White
pKa	9.99±0.46(Predicted)
Storage Condition	Hygroscopic, -20°C Freezer, Under inert atmosphere
Refractive Index	1.496

3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid - Introduction

3-choro-5-(trifluoromethyl)pyridine-2-carboxylic acid is an organic compound with the structural formula of ClC_6H_3(CF_3)NO_2. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: Colorless or yellowish solid.
-Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide and dichloromethane.
-Melting point: about 90-93°C.
-Molecular weight: 233.53g/mol.
-Density: about 1.66 g/cm ^ 3.

Use:
3-chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid is an important intermediate widely used in chemical and pharmaceutical fields. It can be used in the synthesis of pesticides, pharmaceuticals and other organic compounds. For example, it plays an important role in the preparation of pyridine pesticides and herbicides.

Preparation Method:
A commonly used preparation method is to synthesize 3-chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid through the reaction of 3-chloro-5-bromopyridine and cyanoformic acid.

Safety Information:
For any chemical, it is important to follow proper laboratory practices and safety procedures. 3-chroo-5-(trifluoromethyl)pyridine-2-carboxylic acid is an organic compound with a certain degree of danger. Contact with skin, eyes and mucous membranes should be avoided to prevent inhalation or eating. Care must be taken when using or storing the substance, including wearing protective gloves, glasses and respirators. In case of accidental contact, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 15:18:00